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Marek Jakóbisiak Selected Research

Lovastatin (Mevacor)

1/2008Ciglitazone, an agonist of peroxisome proliferator-activated receptor gamma, exerts potentiated cytostatic/cytotoxic effects against tumor cells when combined with lovastatin.
6/2007Potentiated antitumor effects of the combination treatment with statins and pamidronate in vitro and in vivo.
12/2006Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway.
12/2004Lovastatin potentiates antitumor effects of saquinavir against human lymphoma cells.
7/2002Lovastatin potentiates antitumor activity of doxorubicin in murine melanoma via an apoptosis-dependent mechanism.
7/2002Synergistic interaction between highly specific cyclooxygenase-2 inhibitor, MF-tricyclic and lovastatin in murine colorectal cancer cell lines.
2/2002Potentiating antitumor effects of a combination therapy with lovastatin and butyrate in the Lewis lung carcinoma model in mice.

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Marek Jakóbisiak Research Topics

Disease

18Neoplasms (Cancer)
03/2013 - 05/2002
7Melanoma (Melanoma, Malignant)
03/2013 - 07/2002
3Hypercholesterolemia
12/2004 - 02/2002
2Anemia
12/2007 - 05/2002
2Pancreatic Neoplasms (Pancreatic Cancer)
06/2007 - 11/2002
2Breast Neoplasms (Breast Cancer)
12/2006 - 05/2004
2Neoplasm Metastasis (Metastasis)
11/2002 - 07/2002
1Cardiovascular Diseases (Cardiovascular Disease)
06/2010
1Cardiotoxicity
06/2010
1Wounds and Injuries (Trauma)
06/2007
1Hyperlipidemias (Hyperlipidemia)
12/2004
1Lymphoma (Lymphomas)
12/2004
1Carcinoma (Carcinomatosis)
07/2004
1Leukemia
01/2004
1Carcinogenesis
12/2003
1Neutropenia
08/2003
1Leukemia L1210
08/2003
1Coronary Disease (Coronary Heart Disease)
07/2002
1Colorectal Neoplasms (Colorectal Cancer)
07/2002
1Colonic Neoplasms (Colon Cancer)
07/2002
1Adenocarcinoma
05/2002
1Edema (Dropsy)
05/2002
1Lewis Lung Carcinoma
02/2002

Drug/Important Bio-Agent (IBA)

8Cytostatic AgentsIBA
01/2008 - 07/2002
7Interleukin-12 (IL 12)IBA
03/2013 - 08/2002
7Lovastatin (Mevacor)FDA LinkGeneric
01/2008 - 02/2002
51-phenyl-3,3-dimethyltriazene (PDT)IBA
05/2009 - 05/2002
4CytokinesIBA
05/2008 - 12/2003
4Cisplatin (Platino)FDA LinkGeneric
12/2007 - 07/2002
3Pharmaceutical PreparationsIBA
05/2009 - 02/2002
2Bortezomib (Velcade)FDA Link
06/2010 - 05/2009
2Reactive Oxygen Species (Oxygen Radicals)IBA
05/2009 - 12/2003
2Proteins (Proteins, Gene)FDA Link
05/2009 - 08/2002
2Interleukin-15 (Interleukin 15)IBA
05/2008 - 04/2004
2VaccinesIBA
05/2008 - 06/2004
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
05/2008 - 07/2002
2ErythropoietinFDA Link
12/2007 - 05/2002
2InterleukinsIBA
06/2004 - 08/2003
23-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)IBA
05/2004 - 11/2002
2Doxorubicin (Adriamycin)FDA LinkGeneric
05/2004 - 07/2002
2EnzymesIBA
12/2003 - 11/2003
2Dihematoporphyrin Ether (Porfimer Sodium)FDA Link
11/2003 - 05/2002
2Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
11/2003 - 07/2002
1Neoplasm Antigens (Tumor Antigens)IBA
03/2013
1Isoantigens (Alloantigen)IBA
10/2010
1AntigensIBA
10/2010
1Viral AntigensIBA
10/2010
1benzyloxycarbonylleucyl-leucyl-leucine aldehydeIBA
05/2009
1Ubiquitinated ProteinsIBA
05/2009
1Singlet OxygenIBA
05/2009
1Proteasome InhibitorsIBA
05/2009
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
05/2008
1ciglitazoneIBA
01/2008
1PPAR gammaIBA
01/2008
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
12/2007
1Fibronectins (Fibronectin)IBA
06/2007
1matrigelIBA
06/2007
1CollagenIBA
06/2007
1Pamidronate (Aredia)FDA LinkGeneric
06/2007
1Mevalonic Acid (Mevalonate)IBA
12/2006
1BerberineIBA
12/2006
1Saquinavir (Invirase)FDA Link
12/2004
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
12/2004
1Protease Inhibitors (Protease Inhibitor)IBA
12/2004
1Heat-Shock Proteins (Heat-Shock Protein)IBA
07/2004
1OligodeoxyribonucleotidesIBA
06/2004
1Cancer VaccinesIBA
06/2004
1Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)IBA
05/2004
1cerivastatin (Kazak)FDA Link
05/2004
1alanyl-alanyl-phenylalanine chloromethyl ketoneIBA
01/2004
1AntibodiesIBA
12/2003
1Complement System Proteins (Complement)IBA
12/2003
1DNA (Deoxyribonucleic Acid)IBA
12/2003
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
11/2003
1Complementary DNA (cDNA)IBA
11/2003
1Oxidoreductases (Dehydrogenase)IBA
11/2002
1O-(Chloroacetylcarbamoyl)fumagillol (TNP 470)IBA
08/2002
1Annexin A5IBA
07/2002
1Therapeutic UsesIBA
07/2002
13- (3,4- difluorophenyl)- 4- (4- (methylsulfonyl)phenyl)- 2(5H)- furanoneIBA
07/2002
1Carboplatin (JM8)FDA LinkGeneric
05/2002
1phenylhydrazine (phenylhydrazine hydrochloride)IBA
05/2002
1Butyrates (Butyrate)IBA
02/2002
1ProdrugsIBA
02/2002
1tributyrinIBA
02/2002

Therapy/Procedure

4Photochemotherapy (Photodynamic Therapy)
05/2009 - 05/2002
3Immunotherapy
10/2010 - 08/2003
3Injections
05/2008 - 08/2003
3Therapeutics
08/2003 - 02/2002
2Drug Therapy (Chemotherapy)
12/2007 - 05/2002
1Lasers (Laser)
05/2002